Circadia by Dr. Pugliese was built on a single scientific conviction: that the skin operates on a biological clock, running protective processes during the day and shifting to repair and regeneration at night. Products aligned with that rhythm, specifically targeted to support the skin's nocturnal repair cycle, consistently outperform those that apply the same treatment at both times of day. The Anti-Aging Essentials Regimen Kit is the most complete expression of that conviction in a single retail package.
The kit opens with the Amandola Milk Cleanser, a creamy, non-foaming cleanser built around lactic acid and mandelic acid, both alpha hydroxy acids that function as tyrosinase inhibitors. Lactic acid stimulates glycosaminoglycan production, supporting the skin's own moisture matrix. Mandelic acid has additional antimicrobial and brightening properties particularly suited to aging and pigmented skin. Sweet almond milk provides nourishing conditioning. Oat protein delivers antioxidant and anti-irritant support. The result is a cleanser that actively treats the skin rather than simply removing impurities.
Serum 71 is Circadia's cornerstone anti-aging and brightening serum, used in the PM after cleansing. The formula combines tranexamic acid, a proven tyrosinase inhibitor that reduces the appearance of hyperpigmentation and melasma by blocking the enzymatic pathway that produces excess melanin, with azelaic acid, which provides additional brightening, pore-refining, and anti-inflammatory benefits. The next-generation copper peptide is Neodermyl (Methylglucoside Phosphate and Copper Lysinate/Prolinate), a patented copper-based ingredient clinically shown to stimulate collagen and elastin production more effectively than standard copper peptides. Magnesium Carboxymethyl Beta-Glucan is a second-generation beta-glucan with enhanced skin-fortifying and repair-stimulating activity. Applied consistently at night, Serum 71 addresses fine lines, discoloration, uneven texture, and loss of firmness simultaneously.
Cyto-Comm (Cyto-Comm Revitalizing Serum) is the regimen's cellular communication step, applied after Serum 71. The formula centers on Trifluoroacetyl Tripeptide-2, a specialized peptide that targets the process of glycation, the accumulation of advanced glycation end-products (AGEs) that cross-link collagen fibers, stiffening them and accelerating the visible signs of aging. Cyto-Comm detoxifies the skin from glycating agents, protects biomolecules from glycation-induced inflammation, and prevents the cell loss associated with elevated A.G.E. levels. Aminopropyl Ascorbyl Phosphate delivers a stable, water-soluble Vitamin C derivative to support antioxidant protection. Hyaluronic Acid provides immediate hydration. Osmanthus Fragrans Flower Extract contributes calming botanical support. Together, Serum 71 and Cyto-Comm address aging at both the structural level (collagen and elastin) and the molecular level (glycation), a dual-pathway approach that most single-serum anti-aging products can't replicate.
Revita-Cyte Complex (Revita-Cyte Complex Revitalizing Lotion) is the final step of the PM routine, a moisturizing complex that delivers advanced antioxidants, next-generation peptides, and mitochondrial-supporting ingredients that help firm the skin, improve radiance, and restore youthful resilience. It also supports optimal Vitamin D expression, a critical but often overlooked factor in skin cell communication and barrier integrity that diminishes with age. Applied last, it seals the regimen while continuing the active work of the serums beneath it.
Developed by Circadia, a professional-grade skincare brand founded by biochemist and physician Dr. Peter Pugliese. Based in Leesport, Pennsylvania. Formulated for estheticians and their clients, with a science depth that rivals medical-grade skincare without the prescription barrier.
